Current Staff
Quentin Sattentau
Principal Investigator
My BSc in microbiology was from The University of Bristol, UK (1980), and PhD in virology and immunology of HSV-1 infection from The University of London, UK (1985). Postdoctoral studies on the interaction of HIV-1 with CD4 were with Peter Beverley and Robin Weiss at University College London UK, and Richard Axel at the HHMI, Columbia University NY. In 1992 I took up a tenured post as CNRS Director of Research (DR2) at the Centre d’Immunology in Marseille France, where I worked on HIV-1 envelope glycoprotein structure, function and interaction with neutralizing antibodies. After a sabbatical in Geoff Smith’s lab at the Dunn School of Pathology Oxford in 1998, I took up the post of Senior Lecturer at Imperial College in 1999. In 2003 I joined Oxford University where since 2006 I am Professor of Immunology at the Dunn School and Tutorial Fellow at Magdalen College. Current research interests are in two broad areas: i) designing strategies to elicit neutralizing anti-protein and anti-glycan antibodies as vaccination strategies to control HIV-1 and cancer; ii) understanding how phagocytes recognise and efferocytose dying cells via loss of 'don't eat-me' signals. I have ~200 publications, >16,500 citations and an h-index of 69. I teach infection and immunity to undergraduate medical and biomedical science students within the Department and at Magdalen College, and coordinate the Infection FHS Option.E. Quentin. Sattentau@path.ox.ac.uk
Linnea Drexhage
Postdoctoral Researcher
Efferocytosis is the process in which phagocytes engulf and clear apoptotic and dead cells. Impaired efferocytosis can lead to accumulation of apoptotic bodies causing secondary necrosis, which can lead to the production of autoimmune antibodies and lupus-like symptoms. My research is focussed on the protein family of mucin-like molecules expressed on T cells, that through their size and negative charge exhibit strong repulsive properties. I investigate their role as a biophysical barrier on apoptotic T cells during macrophage phagocytosis as well as during T cell activation.E. Linnea.Drexhage@chch.ox.ac.uk
P. + 44 1865 275510
Shengpan Zhang
DPhil Student
I am a final year DPhil student in Molecular Cell Biology in Health and Disease. My project focuses on the cell biological and molecular characterisation of a novel ‘don’t eat me’ barrier molecule called CD43 that modulates macrophage recognition of apoptotic cells and may influence the inflammatory state of macrophages as a consequence of efferocytosis, an essential process for organism development, tissue homeostasis and pathogen control.
E. Shengpan.Zhang@lincoln.ox.ac.uk
P. + 44 1865 275510